Answers to the Questions:
1. D. Adverse Drug Reaction, Definition.
The term adverse drug event is used to describe an injury resulting from administration of drug.
2. B. Pharmacovigilance, definition.
3. A. Thiazide-type diuretics should be used as initial therapy for most patients with hypertension. They can be used either alone or in combination with other anti-hypertensive drug classes which have demonstrated to be beneficial in randomized controlled outcome trials ( E.g. ACE inhibitors, aldosterone receptor blockers, beta blockers, and calcium channel blockers).
4. B. Angina is usually a marker for underlying heart disease. It is a symptom of myocardial ischemia that fibroproliferative response. The functional status of the vascular endothelium also contributes to plaque formation.
5. A. Mild renal dysfunction develops in up to 25% of patients receiving aminoglycosides for several days or more. This is due to the accumulation of these drugs in the proximal tubule. Streptomycin remains to be the least nephrotoxic aminoglycoside.
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