Aluminum Subacetate Solution is used externally as antiseptic and astringent diluted with 20 to 40 parts of water as wet dressing. It can be used to prepare Aluminum Acetate Solution. It is known as Liquor Alumini Subacetatis.
Formulation:
Aluminum Sulfate 160g
Acetic Acid 160ml
Precipitated Calcium Carbonate 70g
Purified Water, qs ______
To make 1000ml
Preparation:
Dissolve the aluminum sulfate in 600ml of cold water, filter then gradually add the precipitated calcium carbonate in portions with constant stirring. Add acetic acid, mix and set the mixture aside for 24 hours. Filter through Buchner funnel with the aid of vacuum if necessary, returning first portion of the filtrate back to funner. Wash the magma on the filter with cold water until the solution measures 1000ml.
Other method or ingredients for producing Aluminum Subacetate Solution may be used provided that the finished product meets the official requirement.
Preparation of Aluminum Acetate Solution
Aluminum Acetate Solution is also known as "Liquor Alumini Acetatis", "Liquor Burowii" or "Burow's Solution." It is a clear, colorless liquid with faint acetous odor and a sweetish, astringent taste. The common use of Aluminum Acetate Solution is antiseptic. By diluting with about 10 to 40 parts of water it can be used already for dressing, astringent or mouth wash and gargle. In veterinary use the dilution with 5 to 10 parts of water can be effective astringent and antiseptic as in burns and various forms of dermatitis.
Formulation:
Aluminum Subacetate Solution 545ml
Glacial Acetic Acid 15ml
Purified water, q.s. _______
To make 1000ml
Preparation:
Mix the two solution and add sufficient quantity of purified water to make 1000ml.
Other process of preparation from
Formulation:
Aluminum Sulfate 87g
Lead Acetate 150g
Purified Water, q.s. _____
To make 1000ml
Preparation:
Dissolve the lead acetate and aluminum sulfate each separately in 525ml of purified water. Then pour the lead acetate solution in thin stream, with constant stirring into the aluminum sulfate solution. Set aside in a cold place about 10oC for 24 hours. Siphon off 1000ml of the clear liquid. If necessary transfer magma to a filter and pour sufficient water through the magma to obtain 1000ml solution.
How To Make Anticoagulant Acid Citrate Dextrose Solution
Anticoagulant Acid Citrate Dextrose Solution is known to be Liquor Acidi Citratis Dextrosi Anticoagulans or ACD Solution. It is use to prevent both blood clotting and crenation or swelling of the cells. Sterile solution is employed for the preparation of blood for fractionation for banked blood, for transfusion and for preparation of citrated human plasma.
Formulation:
Solution A Solution B
Citric Acid 7.30g 4.40g
Sodium Citrate (dihydrate) 22.00g 13.20g
Dextrose (Monohydrate) 24.50g 14.70g
Water for Injection, qs ________ ________
To make 1000ml 1000ml
Preparation:
Dissolve the ingredients, filter till clear, place in suitable container and sterilize.
NF Antiseptic Solution
NF Antiseptic Solution is known as Liquor Antispeticus NF. Can be used as antibacterial for external or oral use, undiluted chiefly as mouthwash and for halitosis. According to medical and dental authorities NF Antiseptic Solution when used as mouthwash does not function as a germicide. The antibacterial activity of the solution is confirmed by microbiological assay procedure. Subculture prepared from a standard culture of Staphylococcus aureus exposed for exactly 5 minutes to NF Antiseptic Solution have exhibit no evidence of bacterial growth during 48 hours of incubation.
Formulation:
Boric Acid 25g
Thymol 0.50g
Chlorothymol 0.50g
Menthol 0.50g
Eucalyptol 0.10g
Methyl Salicylate 0.20ml
Thyme oil 0.01ml
Alcohol 300ml
Purified Water, qs _______
To make 1000ml
Preparation:
Dissolve the Boric acid in 650ml of hot water and cool. Dissolve the other ingredients in the alcohol, mix the 2 solution and add sufficient quantity of water to measure 1000ml. Keep in closed container for 2 hours or more, cool to 10oC filter at this temperature. Use purified talc, if necessary to obtain a clear solution.
Preparation of Calcium Hydroxide Solution
Calcium
Hydroxide Solution is used topically as a protective in various types
of lotion. USP clarifies it as an astringent. Often times included in
the diet of infants to ensure adequate calcium intake. Other names
employed are Liquor Calcii Hydroxidi, Liquor Calcis or Aqua
Calcariae.
Formulation:
Calcium
Hydroxide 5g
Purified
Water 1000ml
Preparation:
Agitate
vigorously and repeatedly during 1 hour the calcium hydroxide in the
cooled purified water. Allow excess of calcium hydroxide to settle
and dispense only the clear supernatant liquid.
Remarks:
Undissolved portion of the mixture is not suitable for preparing
additional quantities of Calcium Hydroxide Solution. Lime water
exposed to air is quickly converted into insoluble carbonate.
Ca(OH)2
+ CO2 → CaCO3
+ H2O
The
reason for keeping lime water over undissolved calcium hydroxide is
to ensure a saturated solution. Calcium hydroxide is sparingly
soluble in water and less soluble in hot water than in cold. A
deposition of calcium hydroxide takes place when heated which
redissolves on cooling.
Boric Acid Solution
Boric Acid Solution
Boric
Acid Solution contains in each 100ml not less than 4.25g of H3BO3.
Other name of it are Liquor Acidi Borici or “Saturated”
Boric Acid Solution. The application of boric acid solution is used
as mild antibacterial for ophthalmic use. It is been done by diluting
with equal volume of sterile purified water to produce approximately
isotonic solution with the lachrymal fluid. A more isotonic solution
may be prepared by using 2.2% boric acid. Solutions of boric acid
will homolyze red blood cells even if made isotonic.
Formulation:
Boric
Acid 50g
Purified
Water, qs _________
To make 1000ml
Preparation:
Heat
350ml of purified water to boiling, add boric acid and agitate until
solution is affected. Immediately add cold purified water to make
1000ml, filter until clear.
Note:
Upon chilling or evaporation of solvent, boric acid solution tends to
deposit crystals or become slightly turbid because of the formation
of minute crystals of boric acid. These redissolve upon heating
again. Dispense the solution only when perfectly clean and without
deposit of crystals. The crystalline form is preferable than the
powdered in making this solution as it is readily soluble and results
to a brilliantly clear solution.
Preparation of Coal Tar Solution
Preparation of Coal Tar Solution
Coal
tar solution is used externally diluted with 9 volumes of water in
treatment of chronic skin disease. Other names of it are liquor
carbonis or liquor carbonis detergens.
Formulation:
Coal
Tar 200g
Polysorbate
80 50g
Wash
Sand 500g
Alcohol,
QS _______
To make 1000ml
Preparation:
Mix
coal tar an wash sand, add polysorbate 80 and 700ml of alcohol.
Macerate for 7 days in closed vessel with frequent agitation. Filter,
rinse the vessel with sufficient alcohol to make 1000ml.
Preparation of Saponated Cresol Solution
Preparation of Hydrogen Peroxide Solution
Preparation of Saponated Cresol Solution
The
saponated cresol solution should be used with caution when it is used
because it is equal to phenol in its poisonous character. It is
employed and widely used as disinfectant for inanimate objects and
exrement. 1:500 solution as mildly antiseptic vaginal douche. Cresol
and soap solution: Lysol (Lenh and Fink), Liquour cresolis saponatus
and liquor cresolis compsitus are other names of it. In preparation
of saponated cresol solution, the pharmacist should be knowledgeable
of other possible substitute ingredients in case the main components
are not the available. Potassium hydroxide may be replaced by 37g of
sodium hydroxide. Alcohol may be replaced by 20ml oleic acid in which
case oil should be warmed to 85o before alkali hydroxide
is added and mixture heated if necessary to complete saponification.
Formula:
Cresol
500ml
Vegetable
oil 350ml
Potassium
Hydoxide 73g
Alcohol
55ml
Purified
Water, QS _________
To make 1000ml
Preparation:
Mix
the vegetable oil and alcohol. Dissolve potassium hydroxide in
purified water immediately add this hot solution to the oil with
vigorous stirring until a small portion of the soap dissolves in hot
purified water to form clear solution (Saponification Test). Add the
cresol to the soap and stir until clear. Lastly, add sufficient
quantity of water to make 1000ml.
Preparation of Formaldehyde Solution
Preparation of Formaldehyde Solution
Formaldehyde
solution contains not less than 37% of formaldehyde (CH2O)
with methanol added to prevent polymerization. It is used as
disinfectant and deodorant. Employed for preserving milk, meat and
other articles of food but prohibited by both national and state
laws. Use to disinfect apartments subjected to infection by spraying
on sheets hung in the room or vapors may be conducted from a
generator. Preserves cadavers, zoological specimens. Known in the
other name as formol or formalin.
Preparation:
Formalin
is made by mixing the vapor of boiling methyl alcohol, while under
pressure, with air in proper quantity. The mixed vapors is allowed to
pass over heated tubes, and then condensing the vapor by passing them
into a copper tank provided with the means for reducing the
temperature to 0o. Sufficient water is added to the
product to contain 37% by weigh of HCHO.
2
HCH2OH + O2 →
2 HCHO + 2 H2O
methanol
oxygen formaldehyde water
Preparation of Hydrogen Peroxide Solution
Each
100ml of hydrogen peroxide solution contains 2.5 – 3.5g of H2O2.
Suitable preservatives may be added totaling to not more than 0.05%.
It is known to be Hydrogen Dioxide Solution or peroxide.
Preparation:
The
solution is prepared by diluting the commercially available
concentration 70 -90% solution which are produced by electrolysis.
Uses:
Active
germicide by virtue of the fact that it releases nascent oxygen. It
possesses a poor penetrability as it releases oxygen rapidly and for
a short period of time. Of value in cleansing wounds where
effervescence (releases oxygen) affords mechanical means for the
removal of tissue debris from inaccessible regions. For this purpose,
solution of 3% or diluted 1.5% is employed. For mouth wash in the
treatment of Vincent's stomatitis 3% hydrogen peroxide solution is
effective, but continued use for this purpose may lead to condition
known as “hairy tongue”. A 2% solution is intended for treatment
of trichomonas vaginalis, vaginitis and of balanitis, as hair bleach.
