IPP REVENUE HITS

Monday, December 29, 2014

Preparations of Elixir: Part 2



Glycyrrhiza Elixir, NF

Other Name: Elixir Glycyrrhiza; Elixir Adjuvans; Licorice Elixir

Formula:

Glycyrrhiza Fluidextract                   125 ml
Aromatic Elixir                                  875 ml
            To make                               1000 ml

Preparation:  Mix and Filter.

Use: Flavored vehicle.



Iso-Alcoholic Elixir, NF

Other Names: Elixir Iso-Alcoholicum; Iso-Elixir

Formula:

Low-Alcoholic Elixir                                a certain volume
High-Alcoholic Elixir                               a certain volume

Preparation: Mix the ingredients.



Adjustment of Iso-Alcoholic Elixir

Low-Alcoholic Elixir
High-Alcoholic Elixir
Suitable as vehicle for preparations of the following alcoholic strength
Undiluted
none
0 – 10%
4 volumes
1 volume
10 – 20%
3 volumes
1 volume
20 – 30%
2 volumes
1 volume
30 – 40%
1 volumes
1 volume
40 – 50%
1 volumes
2 volume
50 – 60%
1 volumes
3 volume
60 – 70 %
none
Undiluted
70% or more

The alcohol strength of the Iso-Alcoholic Elixir to be used with a single liquid galenical in a prescription is approximately the same as that of the galenical. The galenicals of different alcohol strengths called for in one prescription, the strength of the Iso-Alcoholic Elixir should be such as to secure the best solution possible. This will be approximately the average strength of the alcoholic strengths of the several ingredients.

For non-extractive substances, the lowest alcoholic strength of the Iso-Alcoholic Elixir that will yield a perfect solution should be chosen.



Low-Alcoholic Elixir

Formula:

Compound Orange Spirit                    10 ml
Alcohol                                              100 ml
Glycerin                                             200 ml
Sucrose                                               320 g
Purified Water, q.s.                     ____________
             To make                               1000 ml

Preparation:

Mix all the ingredients with 500 ml of purified water, agitate thoroughly from time to time and let stand for 24 hours. Filter through a hard filter paper, returning, if necessary, the first potions of the filtrate until it passes through clear. Dissolve the sucrose in the filtrate by agitation or percolation, and add sufficient of the solvent mixture to make 1000 ml.



High-Alcoholic Elixir

Formula:

Compound Orange Spirit                   4 ml
Saccharin                                            3 g
Glycerin                                           200 ml
Alcohol, q.s.                                ___________
           To make                               1000 ml

Preparation:

Dissolve the compound orange spirit and the saccharin in 700 ml of alcohol, add the glycerin and sufficient alcohol to make the product measure 1000 ml, mix and filter.

Uses:  General vehicle for various medicaments that require solvents of different alcohol strengths. Therefore, when Iso-Alcoholic Elixir is specified in a prescription the proportion of its two ingredients to be used is that which will produce a solution of the required alcohol strength.





Lactated Pepsin Elixir, NF

Other Names: Compound Pepsin Elixir; Compound Digestive Elixir

Formula:
 
Pepsin                                     35 g
Lactic Acid                              1 ml
Glycerine                                250ml
Orange Oil                               2 ml
 Alcohol                                 200 ml
Amaranth Solution                  14 ml
Purified Water, q.s.              _________
              To make                     1000 ml

Preparation:

Add the pepsin to 500 ml of cold purified water previously mixed with the lactic acid. Allow to stand in a cool place until the pepsin is thoroughly softened; stir gently until dissolved, then add the glycerin. Dissolve the orange oil in the alcohol, add the amaranth solution and gradually add this solution to the pepsin solution with gentle stirring. Then add sufficient purified water to make the product measure 1000 ml. Filter, if necessary, to produce a clear solution.

Remarks:
The proteolytic activity of pepsin solutions is reduced by agitation and storage. To compensate for this, an excess of pepsin is used in the formula.

Use: A vehicle for nauseating medicines.

 

Phenobarbital Elixir, USP

Definition: Each 100ml contains 370 – 430 mg of C12H12N2O3.

Formula:

Phenobarbital                        4 g
Alcohol                                 150 ml
Orange Oil                            0.75 ml
Glycerin                               450 ml
Syrup                                   150 ml
Amaranth Solution               10 ml
Purified Water, q.s.         ____________
             To make                  1000 ml

Preparation:

Dissolve the phenobarbital in alcohol. Add the rest of the ingredients and sufficient purified water to make the product measure 1000 ml. Mix and filter, if necessary.

Uses: Sedative and hypnotic. Also in the symptomatic therapy of epilepsy.

Warning: Included in Schedule of Controlled Substances

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