Preparation of Elixir: Part 3

Sodium Bromide Elixir, NF

Other Name: Elixir Sodii Bromidi

Formula:

Sodium Bromide                         175 g

Purified Water                             460 ml

Syrup                                         200 ml

Aromatic Elixir, q.s.              ___________

             To make                       1000 ml

Preparation:

Dissolve the sodium bromide in the purified water. And the syrup and sufficient aromatic elixir to make the product measure 1000 ml. Mix well and filter, if necessary, to produce a clear product.

Possible Uses: Sedative and mild hypnotic. Also in the symptomatic treatment of epilepsy. Dose would be 5 ml.

Warning: Included in Schedule of Controlled Substances

Sodium Butabarbital Elixir, NF

Description: Each 100 ml contains 560 – 630 mg of C₁₀H₁₅N₂NaO₃.

Formula:

Sodium Butabarbital                                   6g

Sodium Saccharin                                      1 g

Compound Orange Spirit                       1.5 ml

Anethole                                              0.034 ml

Alcohol                                                   300 ml

Propylene Glycol                                    350 ml

Tartrazine (FD & C Yellow No. 5)             0.1 g

Purified Water, q.s.                            _________

              To make                                  1000 ml

Preparation:

Dissolve the sodium butabarbital, sodium saccharin, compound orange spirit and anethole in the alcohol. Add the propylene glycol. Dissolve the tartrazine in 50 ml of purified water and add to the first solution. Finally, add sufficient purified water to make the product measure 1000 ml. Mix well and filter, if necessary, to produce a clear elixir.

Uses: Sedative and hypnotic. It is an “intermediate-acting” barbiturate.

Dose: 5 ml

Warning: Included in Schedule of Controlled Substances

Sodium Pentobarbital Elixir, USP

Other Name: Elixir Pentobarbitali or Pentobarbital Elixir

Formula:

Sodium Pentobarbital                           4 g

Diluted Hydrochloric Acid                 6 ml

Glycerin                                            450 ml

Orange Oil                                       0.75 ml

Caramel                                               2 g

Syrup                                               150 ml

Alcohol                                            150 ml

Purified Water, q.s.                     ___________

              To make                            1000 ml

Preparation:

Dissolve the sodium pentobarbital in purified water, add the glycerin, alcohol, orange oil, caramel and syrup. Mix well, add the dilute hydrochloric acid and sufficient purified water to measure 1000 ml. Mix and filter, if necessary.

Uses: Sedative-hypnotic drug

Dose: Orally taken 15 to 300 mg, usually oral – 100 mg at bedtime.

Warning: Included in Schedule of Controlled Substances

Terpin Hydrate Elixir, NF

Other Name: Elixir Terpini Hydratis

Formula:

Terpin hydrate                                  17 g

Sweet Orange Peel Tincture           20 ml

Benzaldehyde                               0.05 ml

Glycerin                                        400 ml

Syrup                                            100 ml

Alcohol                                         430 ml

Purified Water, q.s.                   _________

              To make                         1000 ml

Preparation:

Dissolve the terpin hydrate in the alcohol, add the rest of the ingredients and sufficient quantity of purified water to make 1000 ml. Mix and filter, if necessary.

Dose: Usual dose is 5 ml which is equivalent to 85 mg of terpin hydrate.

Note: The terpin hydrate is dissolved due to the high alcoholic content of the elixir. Sweet orange peel tincture may be replaced by 1 ml of orange oil dissolved in 15 ml of alcohol.

Incompatibilities: Dilution of this elixir with water or liquids with low alcoholic content causes precipitation of the terpin hydrate.

Terpin Hydrate and Codeine Elixir, NF

Other Name: Elixir Terpini Hydratis et Codeine.

Formula:

Codeine                                       2 g

Terpin Hydrate Elixir, q.s.     _________

             To make                      1000 ml

Preparation: 

Dissolve the codeine in sufficient quantity of terpin hydrate elixir to make the product measure 1000 ml.

Uses: Expectorant and sedative used to allay excessive coughing. The value resides primarily on its codeine content.

Doses: Usual is 5 ml, equivalent to 10 mg of codeine and 85 mg of terpin hydrate.

Warning: Included in Schedule of Controlled Substances

 

Preparations of Elixir: Part 2

Glycyrrhiza Elixir, NF

Other Name: Elixir Glycyrrhiza; Elixir Adjuvans; Licorice Elixir

Formula:

Glycyrrhiza Fluidextract                   125 ml

Aromatic Elixir                                  875 ml

            To make                               1000 ml

Preparation:  Mix and Filter.

Use: Flavored vehicle.

Iso-Alcoholic Elixir, NF

Other Names: Elixir Iso-Alcoholicum; Iso-Elixir

Formula:

Low-Alcoholic Elixir                                a certain volume

High-Alcoholic Elixir                               a certain volume

Preparation: Mix the ingredients.

Adjustment of Iso-Alcoholic Elixir

Low-Alcoholic Elixir	High-Alcoholic Elixir	Suitable as vehicle for preparations of the following alcoholic strength
Undiluted	none	0 – 10%
4 volumes	1 volume	10 – 20%
3 volumes	1 volume	20 – 30%
2 volumes	1 volume	30 – 40%
1 volumes	1 volume	40 – 50%
1 volumes	2 volume	50 – 60%
1 volumes	3 volume	60 – 70 %
none	Undiluted	70% or more

The alcohol strength of the Iso-Alcoholic Elixir to be used with a single liquid galenical in a prescription is approximately the same as that of the galenical. The galenicals of different alcohol strengths called for in one prescription, the strength of the Iso-Alcoholic Elixir should be such as to secure the best solution possible. This will be approximately the average strength of the alcoholic strengths of the several ingredients.

For non-extractive substances, the lowest alcoholic strength of the Iso-Alcoholic Elixir that will yield a perfect solution should be chosen.

Low-Alcoholic Elixir

Formula:

Compound Orange Spirit                    10 ml

Alcohol                                              100 ml

Glycerin                                             200 ml

Sucrose                                               320 g

Purified Water, q.s.                     ____________

             To make                               1000 ml

Preparation:

Mix all the ingredients with 500 ml of purified water, agitate thoroughly from time to time and let stand for 24 hours. Filter through a hard filter paper, returning, if necessary, the first potions of the filtrate until it passes through clear. Dissolve the sucrose in the filtrate by agitation or percolation, and add sufficient of the solvent mixture to make 1000 ml.

High-Alcoholic Elixir

Formula:

Compound Orange Spirit                   4 ml

Saccharin                                            3 g

Glycerin                                           200 ml

Alcohol, q.s.                                ___________

           To make                               1000 ml

Preparation:

Dissolve the compound orange spirit and the saccharin in 700 ml of alcohol, add the glycerin and sufficient alcohol to make the product measure 1000 ml, mix and filter.

Uses:  General vehicle for various medicaments that require solvents of different alcohol strengths. Therefore, when Iso-Alcoholic Elixir is specified in a prescription the proportion of its two ingredients to be used is that which will produce a solution of the required alcohol strength.

Lactated Pepsin Elixir, NF

Other Names: Compound Pepsin Elixir; Compound Digestive Elixir

Formula:

 

Pepsin                                     35 g

Lactic Acid                              1 ml

Glycerine                                250ml

Orange Oil                               2 ml

 Alcohol                                 200 ml

Amaranth Solution                  14 ml

Purified Water, q.s.              _________

              To make                     1000 ml

Preparation:

Add the pepsin to 500 ml of cold purified water previously mixed with the lactic acid. Allow to stand in a cool place until the pepsin is thoroughly softened; stir gently until dissolved, then add the glycerin. Dissolve the orange oil in the alcohol, add the amaranth solution and gradually add this solution to the pepsin solution with gentle stirring. Then add sufficient purified water to make the product measure 1000 ml. Filter, if necessary, to produce a clear solution.

Remarks:

The proteolytic activity of pepsin solutions is reduced by agitation and storage. To compensate for this, an excess of pepsin is used in the formula.

Use: A vehicle for nauseating medicines.

 

Phenobarbital Elixir, USP

Definition: Each 100ml contains 370 – 430 mg of C₁₂H1₂N₂O₃.

Formula:

Phenobarbital                        4 g

Alcohol                                 150 ml

Orange Oil                            0.75 ml

Glycerin                               450 ml

Syrup                                   150 ml

Amaranth Solution               10 ml

Purified Water, q.s.         ____________

             To make                  1000 ml

Preparation:

Dissolve the phenobarbital in alcohol. Add the rest of the ingredients and sufficient purified water to make the product measure 1000 ml. Mix and filter, if necessary.

Uses: Sedative and hypnotic. Also in the symptomatic therapy of epilepsy.

Warning: Included in Schedule of Controlled Substances